Alzheimer's

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Stem cells offer hope for recovery and symptom management in Alzheimer's

Network of branching nerve cells — illustration
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Stem cell treatment for Alzheimer's

Alzheimer's is a neurodegenerative disorder that has a significant impact on cognitive functions and daily life. This disease can occur due to various factors such as genetic predisposition, aging, and other unknown causes. Alzheimer's can affect people of various ages and has a profound impact on their mental well-being. Our stem cell treatment for Alzheimer's involves direct administration of allogeneic mesenchymal stem cells to address the underlying causes of this condition and improve cognitive function. This can lead to an improvement in quality of life and a decrease in Alzheimer's symptoms.

How is our stem cell treatment for Alzheimer’s disease performed in Istanbul?

Our regenerative treatments are led by Uzm. Dr. Cihan Bolat, MD, Specialist in Anaesthesiology and Reanimation · Regenerative Medicine. We use mesenchymal stem cells derived from umbilical cord tissue and Wharton’s jelly, and exosomes. Our medical team reviews each patient’s health and medical history to assess treatment suitability and discuss the available options.

Expert stem cell treatment led by Uzm. Dr. Cihan Bolat, MD

Under the leadership of Uzm. Dr. Cihan Bolat, MD, Specialist in Anaesthesiology and Reanimation · Regenerative Medicine, we provide expert treatments tailored to the unique needs of our patients. With our extensive experience and mesenchymal stem cells derived from umbilical cord tissue and Wharton’s jelly, and exosomes at our disposal, we offer an integrated approach to the treatment of Alzheimer's. In our clinic we do not use performance-enhancing substances or components, and we strive for a relaxing atmosphere with a friendly and professional team to help you enjoy your stay.

A closer look

Alzheimer's

Explore your topic. Discuss your questions and personal circumstances with us.

Discuss your situation
Alzheimer's

How does our stem cell treatment for Alzheimer’s disease work?

All our stem cell treatments in Istanbul are assessed and administered by specialists in the field, trained in the United States and Turkey, and not by general practitioners. We do this to ensure the highest level of precision, understanding of the condition and quality of treatment for our patients. We are 100% open and honest with our patients. Not everyone is eligible for our stem cell treatments.

We decline treatment for many patients after our specialist reviews their current health and medical history and determines that treatment is unsuitable. This avoids false promises or expectations when the risks outweigh the benefits. For this reason, and to ensure patient safety in all our treatments, each patient is assessed by the specialist before they can plan their treatment.

  1. Step 1.

    Specialist assessment

    For patients with Alzheimer's, our specialist will need to know the patient's age and previous medical treatments. In addition, he will need to review the test results you will be asked to provide.

  2. Step 2.

    Free telephone consultation with the specialist

    Once the specialist has reviewed the medical records and confirmed your suitability, we will present treatment options and pricing. We also offer a free telephone consultation to discuss your questions and concerns.

  3. Step 3.

    Stem cell preparation

    Once you decide to undergo our treatment, we will send a deposit invoice to begin the process of stem cell preparation so that it is ready for your scheduled treatment. This process can take 5-10 days, depending on current demand and availability.

  4. Step 4.

    Treatment day

    On the day of treatment you can choose to come to our hospital location or use our free transportation to and from our clinic in Istanbul. Our driver will pick you up at your desired location and accompany you to our clinic, where the specialist will administer the treatment, and then take you safely back.

  5. Step 5.

    Follow-up care

    Our follow-up specialist will contact you according to our follow-up schedule to ensure you have all the resources you need for maximum benefits. Your well-being and satisfaction are our top priority.

Your life comes first

More space for what matters to you.

Your questions, your wishes and your everyday life. That is where our conversation begins.

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Frequently asked questions

How much does treatment cost, and what is included?

Costs depend on your assessment and the proposed treatment plan. Request an itemised quotation before making a decision.

The existing treatment information includes transport to and from the clinic, specialist treatment, a personal contact and follow-up. Confirm the exact arrangements in your quotation.

Before booking, request a written quotation covering treatment, tests, transport and follow-up. Confirm whether travel, accommodation, extra sessions and additional care are included. Insurance reimbursement is not automatic; check this with your insurer in advance.

How effective is this stem cell treatment for Alzheimer's?

Potential outcomes vary between people and treatment protocols. Your assessment should cover specific goals, the available research and the remaining uncertainties. Agree on when and how results will be assessed. Another patient’s experience cannot reliably predict your own outcome.

Describe which daily activities are difficult and which changes you want to discuss. A clear baseline helps track progress.

Which risks and side effects should I discuss?

Risks depend on the cell product, the administration method and your health. Ask the doctor to explain possible side effects and complications, how they would be managed and whom to contact after returning home. Injections and infusions are not risk-free.

How is my suitability assessed?

Medical assessment comes before treatment planning. Share your diagnosis, current symptoms, medication, previous treatments and available test results. The specialist considers potential benefits, risks and alternatives. Further assessment may be needed, and treatment may not be appropriate.

Research & insight

The science behind the possibilities.

Selected publications for Alzheimer's

Explore what was actually studied and how the findings relate to this treatment.

Preclinical · animal research2021

Wharton’s jelly exosomes in a memory model

Intranasal exosomes improved spatial memory in a mouse model with Alzheimer-like features. This does not establish efficacy in patients. A correction accompanies this article.

Exosomes from Wharton’s jelly MSCs

Read on PubMedPMID 33725248
Study details
Reference
Zhdanova DY et al. Bull Exp Biol Med, 2021.
DOI: 10.1007/s10517-021-05109-3
Material studied
Exosomes from Wharton’s jelly MSCs
Published correction
Phase I · safety2021

An early safety study in Alzheimer’s disease

Nine patients received cord-blood MSCs through a brain reservoir. Fever and some serious adverse events occurred. Source and route differ from cord-tissue MSCs delivered intravenously, intrathecally or intranasally.

Cord-blood MSCs, not cord-tissue MSCs

Read on PubMedPMID 34521461
Study details
Reference
Kim HJ et al. Alzheimers Res Ther, 2021.
DOI: 10.1186/s13195-021-00897-2
Material studied
Cord-blood MSCs, not cord-tissue MSCs
How should you read these studies?

We select research by condition, cell source and administration, prioritising cord tissue and Wharton’s jelly. This is not a systematic review. A matching cell source does not mean preparation, dose or protocol matches our treatment. Extracellular vesicles, isolated exosomes and secretome are different preparations. Animal and laboratory research explores possible mechanisms; a trial protocol contains no results yet. PubMed inclusion is not treatment approval.

Sources checked: .

Relevance to your situation depends on diagnosis, product and treatment plan.

Discuss the research at your consultation

A personal journey. Support at every step.

From your first question to your return home. Explore the consultation, preparation and follow-up.

Understanding your situation
Understanding your situation
Step 01 — Getting to know you

It starts with your story.

Discuss your questions and the information needed for your evaluation. Your medical history and expectations are our starting point.

Start with your question
From proposal to travel
From proposal to travel
Step 02 — Preparing together

Plan your next step.

Discuss the treatment proposal, travel, accommodation and transfers. Agree on the practical arrangements before your visit.

Discuss your preparation
After your return
After your return
Step 03 — Care & follow-up

Attention that goes further.

Agree on treatment and follow-up arrangements, including whom to contact after you return home and which information to take with you.

Ask about follow-up care

Your first question is enough.

Ask about the treatment, costs or your journey. We can discuss what your next step might be.

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